A bioinformatics approach to study the role of calcium phosphate properties in bone regeneration

Calcium phosphates (CaPs) are extensively used as biomaterials for bone repair and regeneration considered an interesting synthetic alternative natural grafts. However, the regenerative potential of many CaP graft substitutes requires further improvements. The bioactivity CaPs is regulated by a variety properties, including their chemical composition (surface) structural properties. In this study, we performed comprehensive characterization six ceramics that had been previously tested in several vitro vivo studies, allowing us to silico distinguish osteoinductive non-osteoinductive ceramics. numerical parameters obtained from were correlated with osteogenesis-associated gene expression pathways osteoblastic MG63 cells cultured on these results showed, among others, influence both cytoskeleton- extracellular matrix-related such MAPK BMP. bioinformatics approach presented here allows exploring transcriptional landscape induced gaining fundamental knowledge about cell-biomaterial interactions.